Changelog

0.5.1

Added native pedigree JSON template to support direct construction of pedigree files in clinical-genetics.

Added clinical-genetics guidance for structured pedigree data and family-based interpretation.

Added the clinical-genetics Agent Skill.
Added guidance for pedigree identity, typed family and reproductive relationships, clinical states, segregation, and genomic findings.
Added interoperability guidance for FHIR, EHR, biobank, and PLINK workflows.
Updated routing and documentation for the new domain.

Expanded Biology Skills with expert guidance for measurement validity, experimental design, structural biology, and biological statistics.

Added experimental-design, structural-biology, and biological-statistics Agent Skills.
Added guidance for observability and negative evidence, identifier mapping and join cardinality, genomic callability, and population-frequency interpretation.
Added structural guidance for residue identity, isoforms, experimental constructs, predicted structures, and confidence metrics.
Added statistical guidance for experimental units, pseudoreplication, ascertainment, selection, denominators, and target populations.
Updated skill routing and documentation for the expanded domain set.

Added synthetic-biology guidance for personalised mRNA vaccine design.

Added the synthetic-biology Agent Skill.
Added guidance for neoantigen identity, peptide:HLA interpretation, target-set selection under uncertainty, and mRNA polyepitope construct design.
Added clearer separation between biological observations, predictions, selected targets, engineered constructs, and downstream outcomes.
Updated routing and documentation for the new domain.

Expanded Biology Skills with bioinformatics and causal-inference guidance.

Added bioinformatics and quinary-inference Agent Skills.
Added guidance for metadata, provenance, sample identity, QC outputs, qualifying evidence, and qualifying variants.
Expanded genomics coverage for sequencing files, intervals, alignments, variant calls, HGVS nomenclature, coding consequences, and reference provenance.
Added support for QEM and QVSS concepts.
Updated routing and repository documentation.

Initial public release.

Added biology-core and genomics Agent Skills.
Added foundational references for biological context, evidence, identifiers, reference genomes, variants, transcripts, inheritance, phase, and gene expression.
Added contribution, governance, validation, testing, and release infrastructure.